KDM5B expression is suppressed by MYC in a negative feedback loop to promote cell survival.
Chatterjee, T.; Beffert, E.; Dewson, G. S.; Sullivan, D. K.; Anchang, B.; Sears, R. C.; Liefwalker, D.
Show abstract
Both c-MYC and KDM5B are global regulators of gene transcription, cell identity, and master transcription factors in hematopoietic malignancies. In this study we link these two critical factors in a negative feedback loop that controls apoptosis and cell survival. We find the MYC specifically downregulates KDM5B, thereby inhibiting its transcriptional repressive functions. Loss of KDM5B abrogates the cell death response to MYC withdrawal in MYC-dependent cells, indicating KDM5B mediates cell death. We find that KDM5B regulates the MYC network, and specifically demethylates the MYC locus. In summary we have discovered a negative feedback loop between MYC and KDM5B. The MYC-dependent suppression of KDM5B leads to a global increase in H3K4me3 methylation, transcriptional activity, and increase cell survival and tumor progression.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia 95%
- Limited inhibition of multiple nodes in a driver network blocks metastasis 94%
- Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor 94%
Similar papers in this journal
- CHK2 inhibition provides a strategy to suppress hematological toxicity from PARP inhibitors. 95%
- GFI1 cooperates with IKAROS/IKZF1 to activate gene expression in T-cell acute lymphoblastic leukemia 95%
- Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia 94%
Similar papers in this journal
Similar papers in this journal
- The DNA helicase FANCJ (BRIP1) functions in Double Strand Break repair processing, but not crossover formation during Prophase I of meiosis in male mice 94%
- Hrq1/RECQL4 regulation is critical for preventing aberrant recombination during DNA intrastrand crosslink repair and is upregulated in breast cancer. 94%
- DNAJB1-PRKACA fusion protein-regulated LINC00473 promotes tumor growth and alters mitochondrial fitness in fibrolamellar carcinoma 93%
Similar papers in this journal
- Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition 95%
- Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers 95%
- Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.