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Mechanism of clinically relevant neurosecretory and metabolic impairment in Alzheimers and identification of engineered nanotherapy

Shang, Y.; Cho, W. J.; Munj, S. A.; Jena, S. G.; Arslanturk, S.; Patil, S. R.; Qi, X.; Jena, B. P.

2025-04-10 neuroscience
10.1101/2025.04.09.647859 bioRxiv
Show abstract

A central challenge in Alzheimers disease is understanding the mechanism of neuronal secretory dysfunction. By exploiting AI, we reveal how beta-amyloid disrupts key protein interactions within the neuronal secretory machinery. In a combinatorial strategy of reprogramming the neuronal secretory and metabolic components, we established a dual-target therapeutic framework that repairs synaptic and mitochondrial defects to counteract neurodegeneration in Alzheimers.

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The top 7 journals account for 50% of the predicted probability mass.

1
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9
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10
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11
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12
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14
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16
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17
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18
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Top 26%
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19
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Top 59%
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20
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21
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22
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23
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24
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Top 0.4%
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25
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26
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28
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Top 0.6%
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29
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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.