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Multi-omics analysis reveals aspirin is associated with reduced risk of Alzheimer's disease

2025-04-08 pharmacology and therapeutics Title + abstract only
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The urgent need for safe and effective therapies for Alzheimers disease (AD) has spurred a growing interest in repurposing existing drugs to treat or prevent AD. In this study, we combined multi-omics and clinical data to investigate possible repurposing opportunities for AD. We performed transcriptome-wide association studies (TWAS) to construct gene expression signatures of AD from publicly available GWAS summary statistics, using both transcriptome prediction models for 49 tissues from the Ge...

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