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OmniSplice: a framework-free splicing event reporter

Lannes, R.; Fingerhut, J. M.; Yamashita, Y. M. M.

2025-04-08 bioinformatics
10.1101/2025.04.06.647416 bioRxiv
Show abstract

We report the development of a framework-free program to assess splicing events: OmniSplice. This new method comprehensively identifies the end of every exon, and categorizes the RNA sequence read based on the sequence that follows the exon ends. OmniSplice detects not only spliced and nascent reads but also unpredicted reads. Using this method, we detected aberrant splicing events, including backsplicing that we failed to detect in our previous analysis upon depletion of a splicing factor U2AF.

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