Safety, technical and clinical success of the Aperio Hybrid thrombectomy device in acute ischemic stroke, a prospective post-market clinical follow-up study (HYBRID)
Kluner, C.; Sundermann, B.; Iacoban, C.; Behme, D.; Kallenberg, K.; Wunderlich, O.; Turowski, B.; Reith, W.; Liman, T.; Rusche, T.; Nordmeyer, H.; Mathys, C.
Show abstract
Background and PurposeStentretrievers are key devices for endovascular treatment of acute ischemic stroke. Aim of this post market clinical follow-up study was to asses safety and outcomes of interventions using the APERIO(R) Hybrid/Hybrid17|21 thrombectomy device (AHD) in routine clinical use. Materials and MethodsProspective monitored multicentric national registry of patients with acute intracranial vessel occlusion treated with the AHD in Germany between 11/2020 and 06/2023. Inclusion of patients (n = 173) with low pre-stroke morbidity (mRS <= 2). Assessment of technical recanalization success (mTICI >= 2b), periprocedural symptomatic intracranial hemorrhages (sICH), good clinical outcome (mRS <= 2) at 90 days, and secondary outcomes. ResultsRecanalization mTICI [≥] 2b was achieved in 97.1 % of the patients, 84.4 % with the AHD only, including 47.4 % first pass success. Good clinical outcome at 90 days (mRS [≤] 2) was observed in 68.8 %. Good primary safety outcome (no periprocedural sICH) was observed, notably even despite a high rate (79.8 %) of stentretriever oversizing. ConclusionsThe AHD is effective and safe. Technical success, primary safety and clinical outcomes surpassed earlier registries on different stentretrievers of the same and earlier generations. However, further studies are warranted to clarify whether these outcomes reflect true advantages of the device, improvements in thrombectomy setups and techniques, or selection biases. Key messagesO_LIThe most important instruments for endovascular stroke treatment, the stent retrievers, differ significantly in design and knowledge about the effects of these differences is limited. C_LIO_LIThe APERIO(R) Hybrid/Hybrid17|21 thrombectomy device (AHD) is effective and safe. C_LIO_LIFurther studies are warranted to clarify, whether the superior outcomes identified in this registry study reflect true advantages of the AHD. C_LI
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Adjunctive Intra-arterial Urokinase after Successful Endovascular Thrombectomy in Patients with Large Vessel Occlusion Stroke (POST-UK): Study protocol of a multicenter, prospective, randomized, open-label, blinded-endpoint trial 98%
- Prehospital triage of intracranial hemorrhage and anterior large vessel occlusion ischemic stroke: the value of the rapid arterial occlusion evalution 96%
- Large Core Thrombectomy: Feasibility Of Simplified Protocol In Resource-Limited Settings 96%
Similar papers in this journal
- Safety Outcomes of Mechanical Thrombectomy Versus Combined Thrombectomy and Intravenous Thrombolysis in Tandem Lesions 98%
- Early recanalization among patients undergoing bridging therapy with tenecteplase or alteplase 98%
- Prospective Observational Cohort Study Of Tenecteplase Versus Alteplase In Routine Clinical Practice 97%
Similar papers in this journal
- Tenecteplase 0.4 mg/kg in moderate and severe acute ischemic stroke: A pooled analysis of NOR-TEST & NOR-TEST 2A 97%
- Intravenous Thrombolysis before Thrombectomy Improves Functional Outcome after Stroke Independent of Reperfusion Grade 96%
- COVID-19 Infection Is Associated with Poor Outcomes in Patients with Intracerebral Hemorrhage 95%
Similar papers in this journal
- White matter lesions as a prognostic marker of recurrence in cryptogenic stroke with high-risk patent foramen ovale 96%
- Quantification of Patent Foramen Ovale Shunt Severity by Transesophageal Echocardiogram and Transcranial Doppler in Routine Clinical Practice 95%
- Impact of Fludrocortisone on the Outcomes of Subarachnoid Hemorrhage Patients: A Retrospective Analysis 94%
Similar papers in this journal
- Endovascular thrombectomy for the treatment of large ischemic stroke: a systematic review and meta-analysis of randomized control trials 97%
- Safety and efficacy of management for intraprocedural rupture during endovascular treatment for intracranial aneurysms 95%
- Low and Borderline Ankle Brachial Index is Associated with Intracranial Aneurysms – a Retrospective Cohort Study 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.