The addiction neurocircuitry during Resting-State Functional Connectivity fMRI in people with Cannabis User Disorder who tried to cut down or quit
Thomson, H.; Labuschagne, I.; Arun, A. H.; McTavish, E.; Sehl, H.; Clemente, A.; Beyer, E.; Quinones-Valera, M.; Rendell, P.; Terrett, G.; Greenwood, L.-M.; Poudel, G.; Manning, V.; Suo, C.; Lorenzetti, V.
Show abstract
Cannabis use disorder (CUD) affects [~]22M people globally and is characterised by difficulties in cutting down and quitting use, but the underlying neurobiology remains unclear. We examined resting-state functional connectivity (rsFC) between regions-of-interest (ROIs) of the addiction neurocircuitry and the rest of the brain in 65 individuals with moderate-to-severe CUD who reported attempts to cut down or quit, compared to 42 controls, and explored the association between rsFC and cannabis exposure and related problems, to elucidate potential drivers of rsFC alterations. The CUD group showed greater rsFC than controls between ROIs implicated in reward processing and habitual substance use (i.e., nucleus accumbens, putamen, pallidum) and occipito/parietal areas implicated in salience processing and disinhibition. Putamen-occipital rsFC correlated with levels of problematic cannabis use and depression symptoms. CUD appears to show neuroadaptations of the addiction neurocircuitry, previously demonstrated in other substance use disorders.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Relationship Between Depression, Prefrontal Creatine and Gray Matter Volume 96%
- Lasting effects of a single psilocybin dose on resting-state functional connectivity in healthy individuals 94%
- Incident benzodiazepine and Z-drug use and subsequent risk of alcohol- and drug-related problems: a nationwide matched cohort study with co-twin comparison 90%
Similar papers in this journal
- Differences in Genetic Correlations between Posttraumatic Stress Disorder and Alcohol Use Disorder-Related Phenotypes Compared to Alcohol Consumption-Related Phenotypes 94%
- Impulsivity Facets and Substance Use Involvement: Insights from Genomic Structural Equation Modeling 94%
- Acute Effects of Cannabidiol on Hippocampal Blood Flow in People at Clinical High Risk for Psychosis 93%
Similar papers in this journal
- Striatal Dopamine Binding in Anhedonia: A Simultaneous [ 11 C]Raclopride Positron Emission Tomography and Functional Magnetic Resonance Imaging Investigation 93%
- Causal Discovery Analysis Reveals Insights into Psychosis Proneness, Brain Function, and Environmental Factors among Young Individuals 92%
- Structural alterations in a rumination-related network in patients with major depressive disorder 92%
Similar papers in this journal
- Differences in fMRI-based functional connectivity during abstinence or interventions between heroin-dependent individuals and healthy controls 94%
- Common and separable neural alterations in adult and adolescent depression – evidence from neuroimaging meta-analyses 93%
- Common And Distinct Patterns Of Task-Related Neural Activation Abnormalities In Patients With Remitted And Current Major Depressive Disorder: A Systematic Review And Coordinate-Based Meta-Analysis 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.