Multiplex serology reveals age-specific immunodynamics of endemic respiratory pathogens in the wake of the COVID-19 pandemic
Bents, S. J.; Martin, E. T.; Steven-Ayers, T.; Andrews, C.; Adler, A.; Perofsky, A.; Krantz, E. M.; Blazevic, R.; Kimball, L.; Prentice, R.; Hansen, C.; Starita, L.; Han, P.; Englund, J.; Wolter, N.; von Gottberg, A.; Maake, L.; Moyes, J.; Cohen, C.; Boeckh, M.; Hay, J. A.; Waghmare, A.; Viboud, C.
Show abstract
The rebound of endemic respiratory viruses following the COVID-19 pandemic was marked by atypical transmission dynamics, with children experiencing increased disease burden and out-of-season epidemics as restrictions relaxed. Here we used serology from a newly developed quantitative multiplex assay to assess the post-pandemic immunity debt, a drop in immunity due to a lack of endemic virus circulation during COVID-19. We assessed age-specific antibody dynamics in Seattle, Washington, US, across a broad range of respiratory viruses, including influenza, respiratory syncytial virus, seasonal coronaviruses, and SARS-CoV-2. We found that respiratory virus immunodynamics differed between individuals <5 years of age and older individuals, with young children experiencing both larger boosts and quicker waning of antibodies across pathogens. We confirmed that these patterns are upheld in a non-pandemic setting by analyzing influenza serological data from South Africa. We incorporated our serological insights into an influenza transmission model calibrated to epidemiological data from Seattle and show that consideration of age-specific immunodynamics may be important to anticipate the effects of pandemic perturbations.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Changes in transmission of Enterovirus D68 (EV-D68) in England inferred from seroprevalence data 96%
- Heterogeneity in transmissibility and shedding SARS-CoV-2 via droplets and aerosols 95%
- SARS-CoV-2 transmission dynamics in South Africa and epidemiological characteristics of the Omicron variant 95%
Similar papers in this journal
- Reconciling heterogeneous dengue virus infection risk estimates from different study designs 96%
- Climate, demography, immunology, and virology combine to drive two decades of dengue virus dynamics in Cambodia 96%
- In vivo kinetics of SARS-CoV-2 infection and its relationship with a person’s infectiousness 95%
Similar papers in this journal
- Socioeconomic and temporal heterogeneity in SARS-CoV-2 exposure and disease in England from May 2020 to February 2023 95%
- Dynamics of influenza transmission in vampire bats revealed by longitudinal monitoring and a large-scale anthropogenic perturbation 95%
- Burden is in the eye of the beholder: Sensitivity of yellow fever disease burden estimates to modeling assumptions 93%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.