CFTR function in alveolar type 1 cells drives lung liquid secretion and host defense
Suthakaran, S.; Homami, S.; Chavez, D.; Tang, S.; Moore, S. K. L.; Sussman, C.; Zhang, J.; Britto, C. J.; Prince, A.; May, A. J.; Kathiriya, J. J.; Hook, J. L.
Show abstract
Loss of the liquid layer that lines the lungs air-facing surface underpins mechanisms of major lung diseases, but the development of therapies that restore liquid secretion is hampered by an incomplete understanding of the cell types that drive it. Here, we show CFTR function in alveolar type 1 (AT1) cells - a cell type that comprises 95% of the lung surface but is presumed to be unimportant in CFTR-related diseases - is critical to lung liquid secretion and the secretion-mediated clearance of particles and S. aureus from lung alveoli. Our findings reveal essential roles for AT1 cells in lung homeostasis and defense, and they call for a reevaluation of the role of AT1 cells in CFTR-related diseases. We suggest AT1 cells be considered key targets of secretion-restoring therapies.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria 95%
- Bronchus-associated macrophages are positioned for soluble antigen capture from the airway lumen and are capable of local Th2 cell activation 93%
- Atf3 defines a population of pulmonary endothelial cells essential for lung regeneration 93%
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Circulating BMP9 protects the pulmonary endothelium during inflammation-induced lung injury in mice 93%
- Autophagy is impaired in fetal hypoplastic lungs and rescued by administration of amniotic fluid stem cell extracellular vesicles 93%
- A Unique Cellular Organization of Human Distal Airways and Its Disarray in Chronic Obstructive Pulmonary Disease 93%
Similar papers in this journal
- Redundant and additive functions of the four Lef/Tcf transcription factors in lung epithelial progenitors 94%
- TRM Integrins CD103 and CD49a Differentially Support Adherence and Motility After Resolution of Influenza Virus Infection 92%
- SARS-CoV-2 transmission via apical syncytia release from primary bronchial epithelia and infectivity restriction in children epithelia 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.