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Bayesian ordered lattice design for Phase I clinical trials

2025-03-24 oncology Title + abstract only
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We develop a new framework specifically for early Phase I clinical trials called Bayesian Ordered Lattice Design (BOLD). This study is motivated by two key factors. First, Phase I clinical trials typically involve relatively small sample sizes, which can make the use of prior information on dose-limiting toxicity (DLT) rates highly significant. To address this challenge, the proposed Bayesian methodology incorporates prior information and posterior updating to guide dose selection, toxicity moni...

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