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Explicitly modeling genetic ancestry to improve polygenic prediction accuracy for height in a large, admixed cohort of US Latinos: Findings from HCHS/SOL

2025-03-23 genetic and genomic medicine Title + abstract only
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Polygenic scores (PGS) offer moderate to high prediction accuracy for complex traits, but most are developed in European ancestry cohorts, reducing their performance in populations of other ancestries. This study aimed to improve standing height prediction, a heritable and ancestry-influenced trait, in an admixed Latino cohort (HCHS/SOL) by modeling ancestry using principal components (PCs) alongside PGS. SNPs were selected from a large European ancestry GWAS using various p-value thresholds, an...

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