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A novel screening assay for insulin receptor

Stanurova, J.; Cermakova, K.; Zakova, L.; Sacha, P.; Jiracek, J.; Konvalinka, J.

2025-03-20 biochemistry
10.1101/2025.03.20.644157 bioRxiv
Show abstract

Insulin is a key hormone in glucose homeostasis. Its lack causes severe health complications and has to be compensated by regular administration of insulin. Despite intense long-lasting research, a more stable and efficient substitute has yet to be discovered to alleviate patients issues. Here we report the development of a new assay for screening potential insulin receptor ligands based on the DNA-linked inhibitor antibody assay (DIANA). Our assay meets the need for a fast, sensitive, non-radioactive method as an alternative to the commonly used radioligand receptor binding assay.

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