Genetic Determinants Of Major Depressive Disorder (MDD) Among Adult Persons Living With HIV In Uganda.
Nsangi, O. T.; Galiwango, R.; Kinyanda, E.; Sajatovic, M.; Mark, K.; Martin, K.; Katabira, E.; Nabbumba, C.; Megan, S.; Seedat, S.; Kalungi, A.
Show abstract
BackgroundMajor Depressive Disorder (MDD) has a heritable component, with estimates of heritability ranging from 30% to 40%. Depression is a significant comorbidity in people living with HIV (PLWHIV), increasing the risk of suicide-related behaviors. This study investigated the genetic risk loci associated with MDD among adults living with HIV in Uganda, where limited data exist on this relationship. MethodsThe case-control study analyzed 282 samples (139 MDD cases and 143 controls), assessed for MDD at baseline, six months, and one year using the Mini International Neuropsychiatric Interview. Blood samples were collected at these intervals, with DNA genotyping conducted in South Africa using the H3Africa array. Data were analyzed using PLINK2 and GEMMA for quality control and genome-wide association analysis respectively, followed by functional mapping with FUMA. ResultsWhile no significant single nucleotide polymorphisms (SNPs) were identified at the genome-wide threshold, six SNPs were found to be suggestively associated with MDD. These SNPs, which have been associated with other psychiatric conditions like Alzheimers, alcohol use disorder, and bipolar disorder and have not previously been linked to MDD. ConclusionThe study suggests the potential for novel MDD genetic risk loci discovery in PLWHIV and people of African ancestry, especially with larger sample sizes.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Association Study Of Six Candidate Genes With Major Depressive Disorder In The North-Western Population Of Pakistan 95%
- The association of child maltreatment and systemic inflammation in adulthood: A systematic review 93%
- The relationships between impulsivity and mood in bipolar disorder: An ecological momentary assessment study 93%
Similar papers in this journal
- Mendelian randomization integrating GWAS and eQTL data revealed genes pleiotropically associated with major depressive disorder 94%
- mtDNA copy number, mtDNA total somatic deletions, Complex I activity, synapse number and synaptic mitochondria number are altered in schizophrenia and bipolar disorder 93%
- Neurovegetative symptom subtypes in young people with major depressive disorder and their structural brain correlates 92%
Similar papers in this journal
- A novel co-segregating DCTN1 splice site variant in a family with Bipolar Disorder may hold the key to understanding the etiology 95%
- Unveiling sex-based differences in the effects of alcohol abuse: a comprehensive functional meta-analysis of transcriptomic studies 92%
- Reduced Expression of Slc Genes in the VTA and NAcc of Male Mice with Positive Fighting Experience 92%
Similar papers in this journal
- Transdiagnostic neurocognitive deficits in patients with type 2 diabetes mellitus, major depressive disorder, bipolar disorder, and schizophrenia: A 1-year follow-up study 94%
- Causal influence of dietary habits on the risk of major depressive disorder: A diet-wide Mendelian randomization analysis 92%
- Electroconvulsive therapy effects on anhedonia and reward circuitry anatomy: a dimensional structural neuroimaging approach 92%
Similar papers in this journal
- Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants 94%
- Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders 92%
- Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.