Root hair lifespan is antagonistically controlled by autophagy and programmed cell death
Feng, Q.; Zhu, S.; Wang, X.; Liu, Y.; Zhao, J.; Dagdas, Y.; Nowack, M. K.
10.1101/2025.03.18.643910 bioRxivShow abstract
Root hairs are tubular tip-growing extensions of root epidermal cells that enhance root surface area for water and nutrient uptake. While mechanisms governing root hair fate, polarity, and tip growth are well understood, the regulation of root hair longevity remains largely unknown. Here, we show that root hair cells employ high levels of autophagy to promote their lifespan. Loss-of-function mutations in the autophagy regulators ATG2, ATG5, or ATG7 induce a premature, cell-autonomous cell death program. This cell death is activated via a gene regulatory network downstream of the NAC transcription factors ANAC046 and ANAC087. Our findings uncover an antagonistic relationship between autophagy and developmentally controlled cell death in root hair lifespan regulation, with potential implications for optimizing plant nutrient and water uptake in crop breeding. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=193 SRC="FIGDIR/small/643910v1_ufig1.gif" ALT="Figure 1"> View larger version (80K): org.highwire.dtl.DTLVardef@1bd570borg.highwire.dtl.DTLVardef@19db5eborg.highwire.dtl.DTLVardef@11279fborg.highwire.dtl.DTLVardef@661c7_HPS_FORMAT_FIGEXP M_FIG C_FIG
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Autophagosome development and chloroplast segmentation occur synchronously for piecemeal degradation of chloroplasts 95%
- The Arabidopsis SAC9 Enzyme is enriched in a cortical population of early endosomes and restricts PI(4,5)P2 at the Plasma Membrane 95%
- CASP microdomain formation requires cross cell wall stabilization of domains and non-cell autonomous action of LOTR1 95%
Similar papers in this journal
- Deceleration of cell cycle underpins a switch from proliferative- to terminal division in plant stomatal lineage 95%
- Root twisting drives halotropism via stress-induced microtubule reorientation 94%
- Single-Cell Resolution of Lineage Trajectories in the Arabidopsis Stomatal Lineage and Developing Leaf 93%
Similar papers in this journal
- Autophagy promotes organelle clearance and organized cell separation of living root cap cells in Arabidopsis thaliana 95%
- PILS proteins provide a homeostatic feedback on auxin signaling output 95%
- Nature and effective range of non-cell autonomous activator and inhibitor peptides specifying plant stomatal patterning 94%
Similar papers in this journal
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.