Functional and structural profiling of circulation via genetically encoded modular fluorescent probes.
Vittani, M.; Lee, A. B.; Wang, X.; Hiraoka, Y.; Konno, A.; Knak, P. G.; Kusk, P.; Nagao, M.; Asiminas, A.; Courtin, J.; Putranto, M. F.; Nasu, Y.; Tsuno, S.; Ueda, K.; Osuga, Y.; Tsuboi, T.; Bienvenu, T.; Terunuma, M.; Hirai, H.; Nedergaard, M.; Tanaka, K.; Hirase, H.
Show abstract
Sustained labeling of fluids is crucial for their investigation in animal models. Here, we introduce a mouse line (Alb-mSc-ST), where blood and interstitial fluid are labeled with the red fluorescent protein mScarlet and SpyTag. The SpyTag-SpyCatcher technology is exploited to monitor circulating fluid properties by biosensors or detect blood-brain barrier disruption. This approach represents a valuable tool for studying vascular structure, permeability and microenvironment in body organs in vivo.
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