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Leveraging tissue-resident memory T cells for non-invasive immune monitoring via microneedle skin patches
2025-03-21
allergy and immunology
Title + abstract only
View on medRxiv
Show abstract
Detecting antigen-specific lymphocytes is crucial for immune monitoring in the setting of vaccination, infectious disease, cancer, and autoimmunity. However, their low frequency and dispersed distribution across lymphoid organs, peripheral tissues, and blood pose challenges for reliable detection. To address this issue, we developed a strategy exploiting the functions of tissue-resident memory T cells (TO_SCPLOWRMC_SCPLOWs) to concentrate target circulating immune cells in the skin and then samp...
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