Non-invasive glucose measurements in humans with time-gated mid-IR optoacoustic spectroscopy
Prebeck, A.; Stahl, U.; Koch, M.; Ntziachristos, V.
Show abstract
Frequent measurements of blood sugar are essential for the management of diabetes. While finger pricking offers accurate measurements of blood glucose, it is a procedure that causes discomfort and risk of infection. Conversely, minimally invasive biochemical sensors based on micro-needles do not assess glucose in blood but in the interstitial fluid. While most optical sensors also detect in bulk from the interstitial fluid, a depth-gated mid-infrared optoacoustic sensor (DIROS) was recently proposed to non-invasively detect glucose concentrations in blood by means of time-gating. While DIROS was previously demonstrated only in animals, herein we present the first pilot investigation of the sensor in humans, based on a multivariate model fit to measurement data obtained from healthy volunteers (n=5) during an oral glucose tolerance test. By time-gating optoacoustic signals, i.e. selecting time points corresponding to different depths within the skin based on the ultrasound time-of-flight, we confirm in humans an improved measurement accuracy when targeting deeper skin layers, which are rich in vasculature. The results set the first milestone towards depth-dependent in-blood glucose detection in humans and highlight potential for DIROS in clinical application.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A scalable, multi-wavelength, broad bandwidth frequency-domain near-infrared spectroscopy platform for real-time quantitative tissue optical imaging 96%
- Interferometric imaging of thermal expansion for temperature control in retinal laser therapy 95%
- First-in-clinical application of a time-gated diffuse correlation spectroscopy system at 1064nm using superconducting nanowire single photon detectors 94%
Similar papers in this journal
- Targeted spectroscopy in the eye fundus 96%
- Application of Transfer Learning for Rapid Calibration of Spatially-resolved Diffuse Reflectance Probes for Extraction of Tissue Optical Properties 94%
- A combined frequency domain near infrared spectroscopy and diffuse correlation spectroscopy system for comprehensive metabolic monitoring of inspiratory muscles during loading 94%
Similar papers in this journal
Similar papers in this journal
- Opsin-free optical neuromodulation and electrophysiology enabled by a soft monolithic infrared multifunctional neural interface 90%
- Rapid label-free identification of pathogenic bacteria species from a minute quantity 1 exploiting three-dimensional quantitative phase imaging and artificial neural network 90%
- Photonic chip-based multimodal super-resolution microscopy for histopathological assessment of cryopreserved tissue sections 89%
Similar papers in this journal
- Portable Six-Channel Laser Speckle System for Simultaneous Cerebral Blood Flow and Volume Measurement with Potential Application for Characterization of Brain Injury 95%
- Multimodal retinal imaging by visible light optical coherence tomography and phosphorescence lifetime ophthalmoscopy in the mouse eye 92%
- Mid-infrared photoacoustic brain imaging enabled by cascaded gas-filled hollow-core fiber lasers 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.