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Lasting effect of psilocybin on sociability can be blocked by DNA methyltransferase inhibition

Song, C.; Chang, T.; Buchborn, T.; Knopfel, T.

2025-03-11 neuroscience
10.1101/2025.03.10.642385 bioRxiv
Show abstract

The recent renaissance in research on psychedelics such as psilocybin has highlighted their therapeutic potential including their lasting influences on brain function. Here we report that a single systemic administration of the serotonergic psychedelic psilocybin can durably promote social behaviour in the Cntnap2-knockout mouse model of autism. This effect can be blocked by pharmacological inhibition of DNA methyltransferase I, indicating an epigenetic mechanism underlying the long-lasting effect of psilocybin.

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