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Integrated genomic analysis of small intestinal neuroendocrine tumors provides further insights into molecular subgroups and identifies putative driver genes

2025-03-12 oncology Title + abstract only
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Small intestinal neuroendocrine tumors (SI-NETs) are the most common tumor of the small intestine. Despite typically being metastatic at the time of diagnosis, the tumors are usually indolent and associated with a relatively long survival. Nevertheless, some patients fare worse and succumb to the disease soon after diagnosis despite similar stage and grade. To date, molecular prognostic markers are lacking, and our understanding of the disease biology is incomplete. Only CDKN1B is recurrently mu...

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