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ProteoSync, a program for ortholog selection, automated sequence alignment and conservation projection onto protein atomic coordinates

Sicheri, E.; Mao, D.; Sicheri, F.

2025-03-14 bioinformatics
10.1101/2025.03.09.642228 bioRxiv
Show abstract

The projection of conservation onto the surface of a proteins 3D structure is a powerful way of inferring functionally important regions. At present, the workflow for doing so can be involved and tedious. For this reason, we created ProteoSync, a Python program that semi-automates the process. The program creates an annotated sequence alignment of orthologs from a diverse set of selectable species, and enables the fast projection of amino acid conservation onto a predicted or known 3D model in PyMOL[1].

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