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Rare Genetic Variants in Antisense Long Non-coding RNAs Contribute to Obsessive-Compulsive Disorder

2025-03-12 psychiatry and clinical psychology Title + abstract only
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Obsessive-compulsive disorder (OCD) is a prevalent neuropsychiatric disorder with an incompletely understood genetic basis, limiting targeted therapeutic options. Although previous rare variant studies have primarily focused on protein-coding genes, the contribution of rare regulatory non-coding variants remains largely unexplored. We analyzed whole-genome sequencing data from 2,561 OCD cases and 12,974 controls from the All of Us Research Program to investigate rare, conserved variants (minor a...

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