Peripheral Beta-Blockade Differentially Enhances Cardiac and Respiratory Interoception
Tyrer, A.; Fischer Ehmsen, J.; Hoogervorst, K.; Nikolova, N.; Pando-Naude, V.; Holm Steenkjaer, C.; Courtin, A. S.; Fardo, F.; Hauser, T.; Bavato, F.; Allen, M.
Show abstract
Interoception, the perception of internal visceral states, arises from complex brain-body interactions across the central and peripheral nervous systems. Despite noradrenalines key role in these interactions, its specific contribution to interoceptive processes remains unclear. In a placebo-controlled, randomised, within-subject study, we employed computational modelling of interoceptive psychophysics to determine how pharmacological beta-adrenoceptor antagonism controls interoception across cardiac and respiratory domains. Both cardio-selective bisoprolol and non-selective propranolol improved cardiac perceptual sensitivity, with bisoprolol exerting an enhanced effect on cardiac metacognition. In contrast, both beta-blockers increased respiratory perceptual precision, with no corresponding changes in sensitivity or metacognition. These findings reveal a novel dissociation between central and peripheral beta-adrenergic mechanisms in interoception, highlighting the pivotal role of peripheral noradrenaline in regulating multi-organ brain-body interactions. Our results suggest that beta-blockers may provide promising routes for modulating distinct facets of interoception, potentially opening new avenues for intervention in conditions characterised by disrupted bodily self-awareness.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Cortical dopamine reduces the impact of motivational biases governing automated behaviour 95%
- Heartbeat-evoked neural response abnormalities in generalized anxiety disorder during peripheral adrenergic stimulation 93%
- Nicotine dependence (trait) and acute nicotinic stimulation (state) modulate attention but not cognitive control: converging fMRI evidence from Go-Nogo and Flanker tasks 92%
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- L-DOPA modulates activity in the vmPFC, Nucleus Accumbens and VTA during threat extinction learning in humans 93%
- Medial prefrontal cortex stimulation abolishes implicit reactions to threats and prevents the return of fear 93%
- A circuit mechanism for irrationalities in decision-making and NMDA receptor hypofunction: behaviour, computational modelling, and pharmacology 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.