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A monoclonal antibody-based immunoassay reinforces DOPA decarboxylase in cerebrospinal fluid as a diagnostic and prognostic biomarker for Parkinson's disease

2025-02-28 neurology Title + abstract only
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BackgroundNovel supportive diagnostic and prognostic biomarkers for Parkinsons disease (PD) are needed to enable its early diagnosis and inform clinical trials. Proteomic studies have identified cerebrospinal fluid (CSF) DOPA decarboxylase (DDC) as a promising biomarker candidate, but its role has not been well characterized. The aim of this study was to gain further insight into the potential of DDC as biomarker for PD. MethodsWe developed and validated a single molecule counting immunoassay f...

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