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Identification of modifiable plasma protein markers of cardiometabolic risk in children and adolescents with obesity
2025-02-25
endocrinology
Title + abstract only
View on medRxiv
Show abstract
Pediatric obesity is associated with multi-organ inflammation and an increased risk of cardiometabolic disease. To identify novel biomarkers of early-onset obesity-related cardiometabolic risk, we performed targeted proteomics, analyzing 149 proteins related to inflammation and cardiovascular disease in a cross-sectional sample of 2,377 children and adolescents with overweight/obesity and 1,647 with normal weight. In addition, we analyzed 64 circulating inflammation-related proteins in 184 child...
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