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Bridging the scales: leveraging personalized disease models and deep phenotyping to dissect cognitive impairment in schizophrenia
2025-02-27
psychiatry and clinical psychology
Title + abstract only
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Schizophrenia (SCZ) is a highly heritable brain disorder marked by a wide range of changes throughout the central nervous system. These changes include alterations at the molecular and cellular levels, suggesting significant disruptions in synapse function, as well as modifications in brain structure and activity. However, it remains unclear, how changes in molecular synapse biology translate into neurophysiological and ultimately behavioral consequences across scales. Here, we narrow this trans...
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