IMPDH Cytoophidia in the Pancreas: Morphological Dynamics and Metabolic Implications
Huang, Y.; Liu, J.-L.; Zhang, W.
Show abstract
Cytoophidia are filamentous structures formed by metabolic enzymes, playing critical roles in cellular metabolism and regulation. Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo nucleotide synthesis, is known to form cytoophidia and is implicated in cell proliferation, nutrient sensing, and metabolic stress responses. Despite their significance, the behavior of IMPDH cytoophidia under different metabolic conditions, particularly in diabetes, remains poorly understood. This study investigates the distribution, morphology, and assembly patterns of IMPDH cytoophidia in the pancreas of normal and diabetic models. Using immunofluorescence staining, pharmacological interventions (e.g., mycophenolic acid), and glucose tolerance tests, we demonstrate that IMPDH cytoophidia exhibit distinct morphological changes in pancreatic islets under diabetic conditions. Notably, cytoophidia elongation is associated with impaired glucose tolerance, suggesting a potential link between cytoophidia dynamics and metabolic dysfunction. Our findings provide novel insights into the role of IMPDH cytoophidia in metabolic regulation and highlight their potential as therapeutic targets for diabetes and related metabolic disorders.
Matching journals
The top 12 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The Cardiolipin Transacylase Tafazzin Regulates Basal Insulin Secretion and Mitochondrial Function in Pancreatic Islets from Mice 96%
- Acute Inhibition of Adipose Triglyceride Lipase by NG497 Dysregulates Insulin and Glucagon Secretion from Human Islets 96%
- β-Hydroxybutyrate promotes basal insulin secretion while decreasing glucagon secretion in mouse and human islets. 95%
Similar papers in this journal
Similar papers in this journal
- Furin controls β cell function via mTORC1 signaling 96%
- Microvascular homeostasis is compromised in pancreatic islets in a mouse model of beta cell loss and low-grade inflammation 95%
- Liraglutide treatment reverses unconventional cellular defects in induced pluripotent stem cell-derived β cells harboring a partially functional WFS1 variant 95%
Similar papers in this journal
- Increased TGFβ /Activin-Smad2 signaling is associated with pancreatic β-cell dysfunction and glucose intolerance in gestational diabetes mellitus 96%
- Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high fat diet 95%
- LGR4 is essential for maintaining beta-cell homeostasis through suppression of RANK 95%
Similar papers in this journal
- Role of Complexin 2 in the regulation of hormone secretion from the islet of Langerhans 96%
- CYP1A1/1A2 enzymes mediate glucose homeostasis and insulin secretion in mice in a sex-specific manner 95%
- Caloric Restriction recovers impaired β-cell-β-cell coupling, calcium oscillation coordination and insulin secretion in prediabetic mice 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.