Bdnf-Ntrk2 Signaling Promotes but is not Essential for Spinal Cord Myelination in Larval Zebrafish
Russell, K.; Kearns, C. A.; Walker, M.; Knoeckel, C.; Ribera, A.; Doll, C.; Appel, B.
Show abstract
Myelin, a specialized membrane produced by oligodendroglial cells in the central nervous system, wraps axons to enhance conduction velocity and maintain axon health. Not all axons are myelinated, and not all myelinated axons are uniformly wrapped along their lengths. Several lines of evidence indicate that neuronal activity can influence myelination, however, the cellular and molecular mechanisms that mediate communication between axons and oligodendrocytes remain poorly understood. Prior research showed that the neurotrophic growth factor Bdnf and its receptor Ntrk2 promote myelination in rodents, raising the possibility that Bdnf and Ntrk2 convey myelin-promoting signals from neurons to oligodendrocytes. We explored this possibility using a combination of gene expression analyses, gene function tests, and myelin sheath formation assays in zebrafish larvae. Altogether, our data indicate that, although not essential for myelination, Bdnf-Ntrk2 signaling contributes to the timely formation of myelin in the developing zebrafish spinal cord.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Prdm8 regulates pMN progenitor specification for motor neuron and oligodendrocyte fates by modulating Shh signaling response 97%
- A glial cell derived pathway directs regenerating optic nerve axons toward the optic chiasm 96%
- A cell-autonomous role for primary cilia in long-range commissural axon guidance 96%
Similar papers in this journal
Similar papers in this journal
- Single-cell analysis of Rohon-Beard neurons implicates Fgf signaling in axon maintenance and cell survival 97%
- Disruption of grin2A, an epilepsy-associated gene, produces altered spontaneous swim behavior in zebrafish 96%
- Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.