Epigenetic Regulation of Visual System Remodeling During Flatfish Metamorphosis: DNA Methylation Dynamics in Ocular Migration and Visual Adaptation
Guerrero-Pena, L.; Suarez-Bregua, P.; Sanchez-Baizan, N.; Piferrer, F.; Tena, J. J.; Rotllant, J.
Show abstract
Flatfish metamorphosis is characterized by extensive tissue remodeling, associated with a transition from pelagic to benthic lifestyle, being the migration of one eye the most dramatic change. Epigenetic mechanisms exert a pivotal role in developmental programs. This study investigates the DNA methylation profiles of migrating and non-migrating eyes using reduced-representation bisulfite sequencing (RRBS) during three developmental stages of turbot: pre-metamorphosis, climax and post-metamorphosis. Over 31% of all identified regions were hypermethylated during climax stage in both eyes, coinciding with elevated expression of the dnmt3a gene, responsible for de novo methylation. Additionally, transcription factors crucial for retinal ganglion cells (RGCs) development, including the eomesa and tbr1b, exhibited differential methylation and expression between the migrating and non-migrating eye during the climax phase. These findings underscore the significance of DNA methylation in the intricate remodeling of the visual system during turbot metamorphosis, particularly regarding RGC-mediated ocular migration and the transmission of visual signals.
Matching journals
The top 11 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Prediction of sex-determination mechanisms in avian primordial germ cells using RNA-seq analysis 94%
- Cellular pathways during spawning induction in the starlet sea anemone Nematostella vectensis 93%
- Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color. 93%
Similar papers in this journal
- The genome of New Zealand trevally (Carangidae: Pseudocaranx georgianus) uncovers a XY sex determination locus 93%
- Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages 93%
- Gene co-expression networks identify novel candidate genes for moulting and development in the Atlantic salmon louse (Lepeophtheirus salmonis) 92%
Similar papers in this journal
- Panx1b modulates the luminance response and direction of motion in the zebrafish 94%
- Full-length transcriptome maps of reef-building coral illuminate the molecular basis of calcification, symbiosis, and circadian genes 91%
- Insulin-like peptide receptor mediated signaling pathways orchestrate regulation of energy homeostasis in the Pacific oyster, Crassostrea gigas 91%
Similar papers in this journal
- Myomixer is expressed during embryonic and post-larval hyperplasia, muscle regeneration and fusion of myoblats in rainbow trout (Oncorhynchus mykiss) 94%
- Comparative analysis of gonadal transcriptomes between turtle and alligator identifies common molecular cues activated during the temperature-sensitive period for sex determination 93%
- A unique neurogenomic state emerges after aggressive confrontations in males of the fish Betta splendens 91%
Similar papers in this journal
- Use of vivo-morpholinos for gene knockdown in the postnatal shark retina 95%
- PIKfyve is an essential component of the endolysosomal pathway within photoreceptors and the retinal pigment epithelium 93%
- Loss of αBa-crystallin, but not αA-crystallin, increases age-related cataract in the zebrafish lens 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.