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Exploring Causal Association between Neuroticism Subclusters and Risk of Coronary Atherosclerosis: A Mendelian Randomization Analysis based on Genome-Wide Association Studies

2025-02-21 cardiovascular medicine Title + abstract only
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BackgroundUnderstanding the risk factors associated with coronary atherosclerosis (CA)--an evident cardiovascular disease--is vital. This study aimed to explore the causal relationship between neuroticism subclusters and CA, focusing on lipids as mediators, using genome-wide association studies and Mendelian randomization (MR). Methods and ResultsInstrumental variables were selected based on their genetic associations with neuroticism subclusters and CA. Causal effects were primarily assessed u...

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