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Modulated smooth muscle cells accumulate late in human coronary atherosclerosis and are temporally and spatially linked to necrotic core formation

2025-02-20 cardiovascular medicine Title + abstract only
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Background and AimsProliferation of arterial smooth muscle cells (SMCs) and their modulation to alternative mesenchymal phenotypes is a central mechanism in the growth of atherosclerotic lesions. The underlying processes have been studied extensively in mouse models, but a detailed analysis of when and where modulated SMCs accumulate in human atherosclerosis is lacking. The present study mapped modulated SMC subtypes during the progression of human coronary atherosclerosis and explored their ass...

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