Immunogenicity of co-administered vaccine antigens with whole-cell or acellular pertussis vaccines in infancy: a randomised controlled trial

2025-02-21 infectious diseases Title + abstract only

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BackgroundWhole-cell pertussis (wP) and acellular pertussis (aP) vaccines evoke different immune responses to pertussis vaccine antigens. We compared the effect of a heterologous wP/aP/aP primary series (hereafter mixed wP/aP) versus a homologous aP/aP/aP primary schedule (hereafter aP-only) on antibody responses to co-administered vaccine antigens in infants and toddlers. MethodsWe randomised Australian infants in a 1:1 ratio to receive either a mixed wP/aP schedule (pentavalent diphtheria-tet...

Immunogenicity of co-administered vaccine antigens with whole-cell or acellular pertussis vaccines in infancy: a randomised controlled trial

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