Magnetoencephalography Reveals Neuroprotective Effects of COVID-19 Vaccination in Non-Human Primates
Stapleton-Kotloski, J.; Rowland, J.; Davenport, A.; Epperly, P.; Blevins, M.; Godwin, D.; Ewing, D.; Liang, Z.; Sundaram, A. K.; Petrovsky, N.; Porter, K.; Gamble, C. S.; Sanders, J. W.; Daunais, J.
Show abstract
SUMMARY PARAGRAPHCOVID-19, caused by the SARS-CoV-2 virus, can lead to widespread neurological complications, including cognitive deficits and neurodegenerative symptoms, even in the absence of significant structural brain abnormalities. The potential neuroprotective effects of SARS-CoV-2 vaccination remain underexplored. Here, we demonstrate the neuroprotective effects of a psoralen-inactivated SARS-CoV-2 vaccine in a non-human primate model using resting-state magnetoencephalography (MEG), a non-invasive neurophysiological recording technique with sub-millisecond temporal and submillimeter spatial resolution. MEG scans demonstrated substantial preservation of neural activity across multiple brain regions in vaccinated subjects compared to unvaccinated controls following viral challenge. This approach not only underscores the role of vaccination in mitigating severe neurological outcomes but also highlights the capability of MEG to detect subtle yet significant changes in brain function that may be overlooked by other imaging modalities. These findings advance our understanding of vaccine-induced neuroprotection and establish MEG as a powerful tool for monitoring brain function in the context of viral infections.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Glutamate-Weighted Magnetic Resonance Imaging (GluCEST) Detects Effects of Transcranial Magnetic Stimulation to the Motor Cortex 92%
- Whole-brain studies of spontaneous behavior in head-fixed rats enabled by zero echo time MB-SWIFT fMRI 92%
- Shared subcortical arousal systems across sensory modalities during transient modulation of attention 92%
Similar papers in this journal
- Long-term alterations in brain and behavior after postnatal Zika virus infections in infant macaques 93%
- Propofol Disrupts the Functional Core-Matrix Architecture of the Thalamus in Humans 92%
- Disruption of myelin structure and oligodendrocyte maturation in a pigtail macaque model of congenital Zika infection 92%
Similar papers in this journal
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.