Motivational control is implemented by a cingulo-prefrontal pathway
Gandaux, C.; Sallet, J.; Amiez, C.; Autran-Clavagnier, D.; Morel-Latour, V.; Goussi-Denjean, C.; Fontanier, V.; Misery, P.; Lamy, C.; Lamberton, F.; Lavigne, M.; Kremer, E. J.; Wislon, C. R. E.; Procyk, E.
Show abstract
The neuronal connections between the midcingulate cortex (MCC) and the dorsolateral prefrontal cortex (dlPFC) are associated with multiple cognitive functions, including rapid and long-term adaptive processes. Here we show that DREADD-mediated activation of MCC to dlPFC projection in macaques led to increased engagement in a foraging task, but did not alter their trial-to-trial adaptive strategy. We conclude that a critical role for MCC-dlPFC pathway is in the temporally extended control of behaviour rather than in rapid adaptation.
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