Leveraging Comparative Phylogenetics for Evolutionary Medicine: Applications to Comparative Oncology
Mellon, W. J.; Sterner, B.; Agren, A.; Vincze, O.; Marx, M. T.; Kapsetaki, S. E.; Huang, P.-H.; Yavari, B.; McCollum, H. W.; Horowitz, B. N.; Human, H.; Baciu, C.; Richker, H.; Mallo, D.; Maley, C. C.; Harmon, L.; Compton, Z. T.
Show abstract
Comparative phylogenetics provides a wealth of computational tools to understand evolutionary processes and their outcomes. Advances in these methodologies have occurred in parallel with a surge in cross-species genomic and phenotypic data. To date, however, the majority of published studies have focused on classical questions in evolutionary biology, such as speciation and the ecological drivers of trait evolution. Here, we argue that evolutionary medicine in general, and our understanding of the origin and diversification of disease traits in particular, would be greatly expanded by a wider integration of phylogenetic comparative methods (PCMs). We use comparative oncology - the study of cancer across the tree of life - as a case study to demonstrate the power of the approach and show that implementing PCMs can highlight the mode and tempo of the evolutionary changes in intrinsic, species-level disease vulnerabilities.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Phylogeny of the damselfishes (Pomacentridae) and patterns of asymmetrical diversification in body size and feeding ecology 94%
- Diving dinosaurs? Caveats on the use of bone compactness and pFDA for inferring lifestyle 90%
- A unique single nucleotide polymorphism in Agouti Signalling Protein (ASIP) gene changes coat colour of Sri Lankan Leopard (Panthera pardus kotiya) to dark black 90%
Similar papers in this journal
- Genomic comparisons shed light on the adaptive basis of brain size plasticity and chromosomal instability in the Eurasian common shrew 93%
- Estimation of Cross-Species Introgression Rates using Genomic Data Despite Model Unidentifiability 91%
- Evolution of gene expression across species and specialized zooids in Siphonophora 91%
Similar papers in this journal
- Seasonal and comparative evidence of adaptive gene expression in mammalian brain size plasticity 92%
- Isometric Spiracular Scaling in Scarab Beetles: Implications for Diffusive and Advective Oxygen Transport 91%
- Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.