MicroRNA Expression in Asymptomatic Welders: Implications for Biomarker Discovery for Environmentally-Linked Neurodegenerative Disorders
Bargues-Carot, A.; Prado-Rico, J. M.; Imamura Kawasawa, Y.; Cai, J.; Yanosky, J. D.; Zenitsky, G.; Jin, H.; Lewis, M. M.; Ma, P.; Anantharam, V.; Kanthasamy, A.; Garao Rico, A. L.; Hall, M.; Mailman, R. B.; Kanthasamy, A. G.; Huang, X.
Show abstract
Environmental exposures rarely occur in isolation, yet biomarkers capturing early brain responses to complex metal mixtures remain limited. Neuron-derived miRNAs detectable in peripheral blood may provide minimally invasive indicators of brain-related molecular processes. We profiled miRNAs from neuron-derived extracellular vesicles in 66 adults and identified 50 dysregulated miRNAs. Among these, miR-16-5p, miR-93-5p, and miR-486-5p were reduced in individuals with higher exposure levels. Metal mixture models identified Pb as the metal most consistently associated with these miRNAs. To explore the translational relevance of these findings, we integrated brain MRI measures and observed that mediation analyses suggested miR-16-5p may represent a potential pathway linking Pb exposure to iron-sensitive MRI signals (R2*, a marker of brain iron) in the red nucleus. Together, these results suggest circulating neuron-derived miRNAs may capture molecular signatures linking complex metal mixtures, with Pb as a key component, to neuronal regulatory pathways and early brain-related perturbation to real-world exposures.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Brick kiln pollution and its impact on health: A systematic review and meta-analysis 94%
- Prenatal Exposure of Pesticide Mixtures and the Placental Transcriptome: Insights from Trimester-specific, Sex-Specific and Metabolite-Scaled Analyses in the SAWASDEE Cohort 93%
- Using low-cost sensors and GPS to assess spatiotemporal variations in personal exposure to PM2.5 in the Washington State Twin Registry 93%
Similar papers in this journal
- Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model 95%
- Lack of pulmonary fibrogenicity and carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model 95%
- Machine learning identifies phenotypic profile alterations of human dopaminergic neurons exposed to bisphenols and perfluoroalkyls 94%
Similar papers in this journal
- Environmental monitoring and health assessment in an industrial town in central India: A cross-sectional study protocol 94%
- Rationale and study protocol of the MAMELI Cohort study (MApping the Methylation of repetitive elements to track the Exposome effects on health: the city of Legnano as a LIving lab) 94%
- Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism 93%
Similar papers in this journal
- A pilot biomonitoring study of cumulative phthalates exposure among Vietnamese American nail salon workers 95%
- Associations between respiratory health outcomes and coal mine fire PM2.5 smoke exposure: a cross-sectional study 95%
- HIPTox – Hazard Identification Platform to Assess the Health Impacts from Indoor and Outdoor Air Pollutant Exposures, through Mechanistic Toxicology: A single-centre double-blind human exposure trial protocol 93%
Similar papers in this journal
- Next-generation biomonitoring in a cohort of pregnant women from rural Bangladesh 94%
- A comprehensive analysis of racial disparities in chemical biomarker concentrations in United States women, 1999-2014 93%
- In vitro genotoxic and mutagenic potentials of combustion particles from marine fuels with different sulfur contents 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.