The Polymorphisms, Solvent Accessibility and Conservatism of Hepatitis C Virus Nonstructural 5B Protein
Lian, D.
Show abstract
ABSTRACTThe polymorphisms of protein or protein family, that is, the divergences of amino acid and nucleotide sequences have provided much useful information on the divergent evolution of proteins. In this paper, we analyzed the polymorphisms of enzyme NS5B of HCV for which sequence variation among most isolates have been characterized and protein structures of the catalytic domain form of this enzyme are also known. For this protein, we found that solvent accessibility of residues in the protein structure is a strong predictor of whether or not an amino acid will be polymorphic and the residue variability. Apart from polymorphism, we found conservatism at every level among site is universal for this protein. We also found that purifying selection at different levels was strong in the forming of the polymorphisms and conservatism of this protein.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- SARS-CoV-2: Proof of recombination between strains and emergence of possibly more virulent ones 95%
- Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible SARS-CoV-2 variants' spike protein 94%
- Analysis the molecular similarity of least common amino acid sites in ACE2 receptor to predict the potential susceptible species for SARS-CoV-2 94%
Similar papers in this journal
- Characterizations of SARS-CoV-2 mutational profile, spike protein stability and viral transmission 95%
- Global variation in the SARS-CoV-2 proteome reveals the mutational hotspots in the drug and vaccine candidates 93%
- Protein interaction analysis of Plasmodium falciparum circumsporozoite protein variants with human immunoproteins explains RTS,S vaccine efficacy in Ghana 93%
Similar papers in this journal
- Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design 93%
- Water stabilizes an alternate turn conformation in horse heart myoglobin 93%
- Molecular features similarities between SARS-CoV-2, SARS, MERS and key human genes could favour the viral infections and trigger collateral effects 93%
Similar papers in this journal
- Analyses of spike protein from first deposited sequences of SARS-CoV2 from West Bengal, India 94%
- Glibenclamide, ATP and Metformin Increases the Expression of Human Bile Salt Export Pump ABCB11 92%
- Cloning of Human ABCB11 Gene in E. coli required the removal of an Intragenic Pribnow-Schaller Box before its Insertion into Genomic Safe Harbor AAVS1 Site using CRISPR Cas9 92%
Similar papers in this journal
- In silico investigation of the new UK (B.1.1.7) and South African (501Y.V2) SARS-CoV-2 variants with a focus at the ACE2-Spike RBD interface 94%
- Hot-spots and their contribution to the self-assembly of the viral capsid: in-silico prediction and analysis 94%
- Bioinformatic Analysis of Structure and Function of LIM Domains of Human Zyxin Family Proteins 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.