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Methylation quantitative loci analysis in nonsyndromic orofacial clefts
2025-02-12
genetic and genomic medicine
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ObjectivesNonsyndromic orofacial clefts (OFCs) involve complex genetic and environmental factors, with over 60 risk loci accounting for only a minority of estimated heritability and residing in non-coding regions with unclear functional relevance. We hypothesize that some genetic variants alter orofacial cleft risk by modifying DNA methylation (DNAm) at regulatory sequences essential for craniofacial development, acting as methylation quantitative trait loci (meQTLs). MethodsWe analyzed 10 well...
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