High-risk HPV Prevalence and Distribution in Cervical Cancer Screening: Extended Genotyping in Correlation with Cytology and p16/Ki67 Dual Stain Results
Trzeszcz, M.; Mazurec, K.; Mazurec, M.; Jach, R.; Halon, A.
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The prevalence of high-risk human papillomavirus (HR-HPV) in cytology combined with p16/Ki67 status using limited and two types of extended HPV genotyping has not yet been described. A total of 32,724 screening tests results between 2015-2024 were included. The overall HR-HPV-positivity rate was 15.0%. The HR-HPV prevalence in limited genotyping group was 13.9%, in extended genotyping 1 (17.8%), in extended genotyping 2 (17.2%), with statistically significant difference in the proportions of positive/negative cases (p<0.0001). No statistically significant difference was noted between extended genotyping groups (p=0.706). Extended genotyping 1: the highest p16/Ki67-positivity was observed for HR-HPV 33/58 (100.0%) and 31 (58.8%), the lowest for HR-HPV 45 (18.2%), 18 (25.0%) and 59/56/66 (28.9%). Extended genotyping 2: the highest p16/Ki67-positivity was for HR-HPV 16 (66.7%) and 31/33/52/58 (58.8%). A combined approach, implementing new technologies, could help healthcare providers in more informed decisions about patient care, supporting the prevention of cervical precancer and cancer. Statement of SignificanceThe transition to HPV-based cervical cancer screening is progressively advancing. By investigating of HR-HPV prevalence and distribution in limited or extended genotyping, cytology and p16/Ki67 dual-stain, our study aimed to support evidence-based decision-making processes and help guide of medical interventions of public health policies targeted to incorporation of new technologies.
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