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Prediction and Characterization of Genetically Regulated Expression of Target Tissues in Asthma

2025-02-08 genetic and genomic medicine Title + abstract only
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BackgroundGenetic control of gene expression in asthma-related tissues is not well-characterized, particularly for African-ancestry populations, limiting advancement in our understanding of the increased prevalence and severity of asthma in those populations. ObjectiveTo create novel transcriptome prediction models for asthma tissues (nasal epithelium and CD4+ T cells) and apply them in transcriptome-wide association study (TWAS) to discover candidate asthma genes. MethodsWe developed and vali...

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