GPR182 is a lipoprotein receptor for dietary fat absorption
Sun, Z.; Torphy, R. J.; Miller, E. N.; Darehshouri, A.; Vigil, I.; Terai, T.; Eck, E.; Sun, Y.; Guo, Y.; Yee, E. J.; Hu, J.; Kedl, R. M.; Lasda, E. L.; Hesselberth, J. R.; MacLean, P.; Bruce, K. D.; Randolph, G. J.; Schulick, R. D.; Zhu, Y.
Show abstract
The lymphatic system plays a central role in lipid absorption, which transports chylomicrons from the small intestine to the circulation. However, the molecular mechanism by which chylomicrons get into the intestinal lymphatics is unknown. Here we demonstrated that GPR182, a receptor in lymphatic endothelial cells (LECs), mediates dietary fat absorption. GPR182 knockout mice are resistant to dietary-induced obesity. GPR182 ablation in mice leads to poor lipid absorption and thereby a delay in growth during development. GPR182 binds and endocytoses lipoproteins broadly. Mechanistically, loss of GPR182 prevents chylomicrons from entering the lacteal lumen of the small intestine. GPR182 blockage with a monoclonal antibody (mAb) protects mice from dietary induced obesity. Together, our study identifies GPR182 as a lipoprotein receptor that mediates dietary fat absorption.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Loss of CTRP10 results in female obesity with preserved metabolic health 97%
- The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent 97%
- Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity 96%
Similar papers in this journal
- Systemic LSD1 inhibition prevents aberrant remodeling of metabolism in obesity 96%
- Increased energy expenditure and protection from diet-induced obesity in mice lacking the cGMP-specific phosphodiesterase, PDE9 96%
- Deficiency of the hemoglobin-haptoglobin receptor, CD163, worsens insulin sensitivity in obese male mice 96%
Similar papers in this journal
- Long-term ketogenic diet causes hyperlipidemia, liver dysfunction, and glucose intolerance from impaired insulin trafficking and secretion in mice 95%
- TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and -independent mitophagy 95%
- Transcriptional regulation of adipocyte lipolysis by IRF2BP2 95%
Similar papers in this journal
- Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice 97%
- Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis 96%
- Hepatic Mitochondrial Remodeling is Mechanistically Linked to Insulin Resistance in Nonalcoholic Fatty Liver Disease 96%
Similar papers in this journal
- Liver-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice 97%
- The human glucocorticoid receptor variant rs6190 promotes blood cholesterol and atherosclerosis 96%
- The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/beta-catenin to RTK/MAPK signaling 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.