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Optimal membrane fluidity modulates biofilm formation in Escherichia coli

Hong, Y.; Qin, J.; Totsika, M.

2025-02-02 microbiology
10.1101/2025.02.02.635587 bioRxiv
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IMPACT STATEMENTMembrane fluidity plays a crucial role in bacterial fitness and adaptation to cope rapid environmental changes. While high membrane fluidity promotes robust biofilm formation in Klebsiella pneumoniae, studies in several other species, including Salmonella enterica, suggest that biofilm formation is associated with reduced fluidity. This paradox may reflect the complex relationship between lipid composition and biofilm formation. Our findings demonstrated that both low and high extremes of lipid fluidity restrict biofilm formation. We propose that the required fluidity for biofilm growth, relative to that required for planktonic growth, may differ between species and are readily adjusted during lifestyle transitions.

Published in mLife · training set

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.