Sialidases derived from Gardnerella vaginalis remodel the sperm glycocalyx and impair sperm function
Dohadwala, S.; Shah, P.; Farrell, M. K.; Politch, J.; Marathe, J.; Costello, C. E.; Anderson, D. J.
Show abstract
Bacterial vaginosis (BV), a dysbiosis of the vaginal microbiome, affects approximately 30 percent of women worldwide (up to 50% in some regions) and is associated with several adverse health outcomes including preterm birth and increased incidence of sexually transmitted infections (STIs). BV-associated bacteria such as Gardnerella vaginalis and Prevotella timonensis damage the vaginal mucosa through the activity of sialidase enzymes that remodel the epithelial glycocalyx and degrade mucin glycoproteins. This damage may contribute to adverse health outcomes. However, whether BV-associated glycolytic enzymes also damage sperm has not yet been determined. Here, we show that sialidase-mediated glycocalyx remodeling of human sperm increases sperm susceptibility to damage and adversely affects their function in vitro. Specifically, we report that sperm motility was not adversely affected by sialidase treatment, but desialylated human sperm demonstrate increased susceptibility to agglutination and complement-mediated cytotoxicity as well as impaired transit through cervical mucus. Our results demonstrate mechanisms by which BV-associated sialidases affect sperm survival and function and potentially contribute to adverse reproductive outcomes such as infertility.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- An oviduct glycan increases sperm lifespan by diminishing ubiquinone and production of reactive oxygen species 93%
- Maternal nutritional stress alters sperm competence in male mice offspring leading to reduced fertility 92%
- Transcriptional profiling of mucus production and modification in rhesus macaque endocervical cells under hormonal regulation 91%
Similar papers in this journal
- Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology 92%
- Thymic stromal lymphopoietin contributes to endometriotic lesion proliferation and disease-associated inflammation. 90%
- The dysregulated IL-23/TH17 axis in endometriosis pathophysiology 90%
Similar papers in this journal
- Redox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activation and sperm motility in mice 94%
- Shedding light on the control of CatSper Ca2+ channels by cAMP and chemicals used to probe cAMP signaling 92%
- The sodium-proton exchangers sNHE and NHE1 control plasma membrane hyperpolarization in mouse sperm. 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.