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Transpulmonary proteome gradients identify pathways involved in the development of pulmonary vascular disease in heart failure

2025-02-03 cardiovascular medicine Title + abstract only
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Background and AimsSome, but not all, patients with heart failure (HF) develop pulmonary vascular disease (PVD), which contributes to poor prognosis. Mechanisms leading to PVD in HF are poorly understood. Unbiased analysis of transpulmonary gradients may identify mediators of PVD by finding proteins consumed or elaborated across the lungs. Methods21 controls and 160 HFrEF patients underwent pulmonary artery (PA) catheterization with blood sampling from postcapillary (wedged balloon) and precapi...

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