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Polygenic scores for disease risk are not associated with clinical outcomes in Parkinson's disease

2025-02-03 neurology Title + abstract only
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Polygenic risk scores (PRS) in Parkinsons disease (PD) are associated with disease risk. Recently, pathway-specific PRS have been created to take advantage of annotations inking variants to biological pathways or cell types. Here, we investigated 8 biological pathways or regions of open chromatin using pathway-specific PRS: alpha-synuclein pathway, adaptive immunity, innate immunity, lysosomal pathway1, endocytic membrane-trafficking pathway, mitochondrial pathway, microglial open chromatin sing...

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