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Long term improvement in Alzheimers Disease with Transcranial Direct Current Stimulation

AGGARWAL, A.

2025-01-28 neuroscience
10.1101/2025.01.26.634937 bioRxiv
Show abstract

The goal of this work was to integrate results from clinical trials related to transcranial direct current stimulation (tDCS) treatment of Alzheimers disease (AD) into a machine learning model of the disease to understand its impact on disease progression over a decade. tDCS is a new emerging treatment modality for AD. The impact of tDCS has so far been only sparsely studied in AD patients over a short duration in small sample sizes. Since AD is a progressive disease, it is useful to know about the impact of tDCS over a longer duration and predict the duration and site of treatment. This paper integrates limited data from tDCS treatment of AD patients and extrapolates it to a decade using the AD prediction model (ADPM). Based on this, it provides guidelines for best site and duration of treatment for a patient with AD.

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