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Ancient origin of an urban underground mosquito

Haba, Y.; Aardema, M. L.; Afonso, M. O.; Agramonte, N. M.; Albright, J.; Alho, A. M.; Almeida, A. P. G.; Alout, H.; Alten, B.; Altinli, M.; Amara Korba, R.; Andreadis, S. S.; Anghel, V.; Arich, S.; Arsenault-Benoit, A.; Atyame, C.; Aubry, F.; Avila, F. W.; Ayala, D.; Azrag, R. S.; Babayan, L.; Bear, A.; Becker, N.; Bega, A. G.; Bejarano, S.; Ben-Avi, I.; Benoit, J. B.; Boubidi, S. C.; Bradshaw, W. E.; Bravo-Barriga, D.; Bueno-Mari, R.; Busic, N.; Cabanova, V.; Cabeje, B.; Caputo, B.; Cardo, M. V.; Carpenter, S.; Carreton, E.; Chouaibou, M. S.; Christian, M.; Coetzee, M.; Conner, W. R.; Cornel,

2025-02-05 evolutionary biology
10.1101/2025.01.26.634793 bioRxiv
Show abstract

Understanding how life is adapting to urban environments represents an important challenge in evolutionary biology. Here we investigate a widely cited example of urban adaptation, Culex pipiens form molestus, also known as the London Underground Mosquito. Population genomic analysis of [~]350 contemporary and historical samples counter the popular hypothesis that molestus originated belowground in London less than 200 years ago. Instead, we show that molestus first adapted to human environments aboveground in the Middle East over the course of >1000 years, likely in concert with the rise of agricultural civilizations. Our results highlight the role of early human society in priming taxa for contemporary urban evolution and have important implications for understanding arbovirus transmission.

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