Gating of hair cell Ca2+ channels governs the activity of cochlear neurons
Karagulyan, N.; Thirumalai, A.; Michanski, S.; Qi, Y.; Fang, Q.; Wang, H.; Ortner, N. J.; Striessnig, J.; Strenzke, N.; Wichmann, C.; Hua, Y.; Moser, T.
Show abstract
Our sense of hearing processes sound intensities spanning six orders of magnitude. In the ear, postsynaptic spiral ganglion neurons (SGNs) tile this intensity range with their firing rate codes. Presynaptic inner hair cells (IHCs) vary Ca2+-influx among their active zones (AZs) diversifying glutamate release and likely contributing to SGN firing diversity. Here we show that low-voltage activation of IHC-Ca2+-influx of mice, modeling the human CaV1.3A749G mutation, increases spontaneous SGN-firing and lowers sound threshold. Altered synaptic morphology in CaV1.3A749G/A749G mice already at ambient sound levels of standard mouse husbandry indicates a risk for noise-induced alterations in CaV1.3A749G patients. We conclude that heterogeneous voltage-dependence of CaV1.3 activation among IHC-AZs contributes to the diversity of SGN firing for sound intensity coding and synaptic vulnerability.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells 96%
- Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses 96%
- Postsynaptic GluA3 subunits are required for the appropriate assembly of AMPA receptor GluA2 and GluA4 subunits on mammalian cochlear afferent synapses and for presynaptic ribbon modiolar-pillar morphological distinctions 95%
Similar papers in this journal
- ISL1 is necessary for auditory neuron development and contributes towards tonotopic organization 95%
- Experience-dependent structural plasticity at pre- and postsynaptic sites of layer 2/3 cells in developing visual cortex 95%
- A silent Kv channel subunit shapes PV neuron action potential waveform and short-term synaptic plasticity during high-frequency firing 95%
Similar papers in this journal
- Cell-type-specific plasticity in synaptic, intrinsic, and sound response properties of deep-layer auditory cortical neurons after noise trauma 96%
- A critical role for CaMKII in behavioral timescale synaptic plasticity in hippocampal CA1 pyramidal neurons. 96%
- Sodium channel endocytosis drives axon initial segment plasticity 95%
Similar papers in this journal
- Purinergic signaling controls spontaneous activityin the auditory system throughout early development 95%
- RIM-Binding Protein 2 organizes Ca2+ channel topography and regulates release probability and vesicle replenishment at a fast central synapse 95%
- Controlling the bioelectrical properties of neurons with ferritin-based Magnetogenetics 95%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.