Regulation of hematopoietic stem cell (HSC) proliferation by Epithelial Growth Factor Like-7 (EGFL7)
Kulkarni, R.; Goda, C.; Rudich, A.; Karunasiri, M.; Urs, A. P.; Bustos, Y.; Balcioglu, O.; Li, W.; Chidester, S.; Rodgers, K. A.; Garfinkle, E.; Patel, A.; Miller, K. E.; Popovich, P. G.; Elf, S.; Garzon, R.; Dorrance, A. M.
Show abstract
Understanding the pathways regulating normal and malignant hematopoietic stem cell (HSC) biology is important for improving outcomes for patients with hematologic disorders. Epithelial Growth Factor Like-7 (EGFL7) is [~]30 kDa secreted protein that is highly expressed in adult HSCs. Using Egfl7 genetic knock-out (Egfl7 KO) mice and recombinant EGFL7 (rEGFL7) protein, we examined the role of Egfl7 in regulating normal hematopoiesis. We found that Egfl7 KO mice had decreases in overall BM cellularity resulting in significant reduction in the number of hematopoietic stem and progenitor cells (HSPCs), which was due to dysregulation of normal cell-cycle progression along with a corresponding increase in quiescence. rEGFL7 treatment rescued our observed hematopoietic defects of Egfl7 KO mice and enhanced HSC expansion after genotoxic stress such as 5-FU and irradiation. Furthermore, treatment of WT mice with recombinant EGFL7 (rEGFL7) protein expands functional HSCs evidenced by an increase in transplantation potential. Overall, our data demonstrates a role for EGFL7 in HSC expansion and survival and represents a potential strategy for improving transplant engraftment or recovering bone marrow function after stress.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- CD99 Promotes Self-renewal in Hematopoietic Stem Cells and Leukemia Stem Cells by Regulating Protein Synthesis 97%
- Endoplasmic reticulum associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity 97%
- Epo-IGF1R crosstalk expands stress-specific progenitors in regenerative erythropoiesis and myeloproliferative neoplasm 96%
Similar papers in this journal
- Mitochondria Regulate the Cell Fate Decisions of Megakaryocyte-Erythroid Progenitors 96%
- Clonal analysis of fetal hematopoietic stem/progenitor cell subsets reveals how post-transplantation capabilities are distributed 96%
- GABA produced by multiple bone marrow cell types regulates hematopoietic stem and progenitor cells 95%
Similar papers in this journal
- Inflammatory signals from fatty bone marrow supports the early stages of DNMT3a driven clonal hematopoiesis 97%
- Multi-Modal Profiling of Human Fetal Liver-Derived Hematopoietic Stem Cells Reveals the Molecular Signature of Engraftment Potential 95%
- Engineered niches support the development of human dendritic cells in humanized mice 94%
Similar papers in this journal
- Cell size is a determinant of stem cell potential during aging 96%
- Inflammatory CD4/CD8 double positive human T cells arise from reactive CD8 T cells and are sufficient to mediate GVHD pathology 96%
- Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.