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Rare Variant Analyses in Ancestrally Diverse Cohorts Reveal Novel ADHD Risk Genes

2025-01-17 psychiatry and clinical psychology Title + abstract only
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Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder, but its genetic architecture remains incompletely characterized. Rare coding variants, which can profoundly impact gene function, represent an underexplored dimension of ADHD risk. In this study, we analyzed large-scale DNA sequencing datasets from ancestrally diverse cohorts and observed significant enrichment of rare protein-truncating and deleterious missense variants in highly evolutionarily co...

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