Audiovisual gamma stimulation enhances hippocampal neurogenesis and neural circuit plasticity in aging mice
Trinchero, M.; Herrero, M.; Mugnaini, M.; Arredondo, A. A.; Benas, S.; Satorre, I.; Kropff, E.; Schinder, A.
Show abstract
Gamma oscillations are disrupted in various neurological disorders, including Alzheimers disease (AD). In AD mouse models, non-invasive audiovisual stimulation (AuViS) at 40 Hz enhances gamma oscillations, clears amyloid-beta, and improves cognition. We investigated mechanisms of circuit remodeling underlying these restorative effects by leveraging the sensitivity of hippocampal neurogenesis to activity in middle-aged wild-type mice. AuViS increased progenitor cell proliferation, neuronal differentiation and morphological maturation of newborn granule cells, promoting their synaptic integration. While visual or auditory stimuli alone induced dendritic growth, axonal changes required combined audiovisual stimulation. The actions of AuViS involved neurotrophin pathways, as shown by the lack of effect upon TrkB signaling blockade. These results reveal widespread plasticity mechanisms triggered by AuViS, a therapeutic approach currently proposed for treating neurological disorders in humans.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Theta activity paradoxically boosts gamma and ripple frequency sensitivity in prefrontal interneurons 96%
- Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice 96%
- microRNA-218-5p Coordinates Scaling of Excitatory and Inhibitory Synapses during Homeostatic Synaptic Plasticity 96%
Similar papers in this journal
- Disruption of the grid cell network in a mouse model of early Alzheimer's disease 96%
- Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines 96%
- Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication 95%
Similar papers in this journal
- KAT6A deficiency impairs cognitive functions through suppressing RSPO2/Wnt signaling in hippocampal CA3 96%
- Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines 96%
- A critical role for CaMKII in behavioral timescale synaptic plasticity in hippocampal CA1 pyramidal neurons. 96%
Similar papers in this journal
- Restoring Glutamate receptosome dynamics at synapses rescues Autism-like deficits in Shank3-deficient mice. 96%
- Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation 96%
- Neural stem and progenitor cells support and protect adult hippocampal function via vascular endothelial growth factor secretion. 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.