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Ag+-regulated aptamers to thrombin

Alieva, R.; Sokolova, S.; Oleynikov, I.; Novikov, R.; Zatsepin, T.; Aralov, A.; Zavyalova, E.

2025-01-09 biochemistry
10.1101/2025.01.09.632085 bioRxiv
Show abstract

Nucleic acid aptamers are artificial recognition elements with high potential in biotechnology. Approaches for aptamer affinity optimization and activity regulation are required for aptamer-based nanodevices. Here thrombin aptamer affinity was increased by a single nucleotide modification with 7,8-dihydro-8-oxo-1,N6-ethenoadenine. Whereas a double modification makes the aptamer activity Ag+-dependent.

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